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Improved tacrolimus skin permeation by co-encapsulation with clobetasol in lipid nanoparticles: Study of drug effects in lipid matrix by electron paramagnetic resonance

作者： Lígia Marquez Andradea. Luis Antônio Dantas Silvaa. Anna Paula Krawczyk-Santosa. Isabella Cristina de S.M.Amorima. Priscila Bianca Rodrigues da Rochaa. Eliana Martins Limab. Jorge Luiz V.Anjosc. Antonio Alonsod. Ricardo Neves Marretoa. Stephânia Fleury Taveiraa.

a

Laboratory of Nanosystems and Drug Delivery Devices (NanoSYS), School of Pharmacy - Universidade Federal de Goiás (UFG), Rua 240, Setor Leste Universitário, 74.605-170 Goiânia-GO, Brazil

b

Laboratory of Pharmaceutical Technology, School of Pharmacy - Universidade Federal de Goiás (UFG) – Praça Universitária, Setor Universitário, 74.605-220 Goiânia-GO, Brazil

c

Physics Department, Universidade Federal de Goiás (UFG), Campus Catalão - Av. Dr. Lamartine Pinto de Velar, 1120, St. Universitário, 74.704-020 Catalão-GO, Brazil

d

Biophysics Laboratory, Physics Institute - Universidade Federal de Goiás (UFG), Campus Samambaia - Caixa Postal 131, 74.0001-970 Goiânia-GO, Brazil